Professor, Department of rehabilitation School of Nursing
TEL：86-431-85622010
E-mail：lishengwang@jlu.edu.cn
Personal Profile
Research direction
1. Stem cell gene therapy and regenerative medicine
2. Biological therapy and tissue regeneration rehabilitation
3. National Key Research and Development Program, 2017YFA0105303
4. National 863 Project, 2012AA020807
5. National 863 Project, 2012AA02A211
6. National 973 Project, 2012AA02A211
7. The national natural science fund projects, 81170460
8. National Natural Science Foundation of China, no.81470320
9. Director of China Medical Biotechnology Association
10. Standing Committee of Regenerative Medicine Specialty Committee, China Medical Biotechnology Association
11. Standing Committee of Gene Therapy Professional Committee of China Medical Biotechnology Association
12. Editorial Board of Chinese Journal of Experimental Hematology
13. Editorial Board of Chinese Journal of Medical Biotechnology
14. Invited Editorial Board member, Chinese Journal of Plateau Medicine and Biology
Recent Publications and Presentations
1、Wang L, Wang H, Zhang Q, Yang Z, Kong F, Wu CT.Hepatocyte Growth Factor Gene Therapy for Ischemic Diseases.Hum Gene Ther. 2018. doi: 10.1089/ hum. 2017. 217.
2、Liu Z, Yang Y, Zhang X, Wang H, Xu W, Wang H, Xiao F, Bai Z, Yao H, Ma X, Jin L, Wu CT, Seth P, Zhang Z, Wang L*. An oncolytic adenovirus encoding decorin and GM-CSF inhibits tumor growth in a colorectal tumor model by targeting pro-tumorigenic signals and via immune-activation. Hum Gene Ther. 2017 Aug; 28(8): 667-680.
3、Jia Q, Sun H, Xiao F, Sai Y, Li Q, Zhang X, Yang S, Wang H, Wang H, Yang Y, Wu CT, Wang L*. miR-17-92 promotes leukemogenesis in chronic myeloid leukemia via targeting A20 and activation of NF-κB signaling. Biochem Biophys Res Commun. 2017;487(4):868-874.
4、Zhang X, Wang H, Wang H, Xiao F, Seth P, Xu W, Jia Q, Wu C, Yang Y, Wang L*. SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation. Int J Mol Sci. 2017；12;18(4).
5、Shi XF, Wang H, Kong FX, Xu QQ, Xiao FJ, Yang YF, Ge RL,Wang LS*. Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. Exp Cell Res 2017;351(1):74-81.
6、Gao Z, Wang H, Xiao FJ, Shi XF, Zhang YK, Xu QQ, Zhang XY, Ha XQ,Wang LS*. SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells. Int J Biochem Cell Biol. 2016 S1357-2725(16)30042-5
7、Shi XF, Wang H, Xiao FJ, Yin Y, Xu QQ, Ge RL,Wang LS*. MiRNA-486 regulates angiogenic activity and survival of mesenchymal stem cells under hypoxia through modulating Akt signal. Biochem Biophys Res Commun. 2016. pii: S0006-291X(16)30084-5.
8、Wang H, Sun RT, Li Y, Yang YF, Xiao FJ, Zhang YK, Wang SX, Sun HY, Zhang QW, Wu CT,Wang LS*. HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity. PLoS One. 2015 ;10(5):e0124420.
9、Sun H, Cui C, Xiao F, Wang H, Xu J, Shi X, Yang Y, Zhang Q, Zheng X, Yang X, Wu C,Wang L*. miR-486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON. Hepatol Res.
10、Yang Y, Liu X, Xiao F, Xue S, Xu Q, Yin Y, Sun H, Xu J, Wang H, Zhang Q, Wang H,Wang L*. Spred2 modulates the erythroid differentiation induced by imatinib in chronic myeloid leukemia cells. PLoS One. 2015 ;10(2):e0117573. IF3.23
11、Xu J, Sun HY, Xiao FJ, Wang H, Yang Y, Wang L, Gao CJ, Guo ZK, Wu CT,Wang LS*. SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling. Biochem Biophys Res Commun. 2015 ;460(2):409-15. IF2.30
12、Wang LS, Li L, Li L, Chu S, Shiang KD, Li M, Sun HY, Xu J, Xiao FJ, Sun G, Rossi JJ, Ho Y, Bhatia R. MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors. Blood. 2015 Feb 19;125(8):1302-13.
13、Yin Y, Sun H, Xu J, Xiao F, Wang H, Yang Y, Ren H, Wu CT, Gao C,Wang L*. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2014 Sep 22:1-8.
14、Yang YF, Xue SY, Lu ZZ, Xiao FJ, Yin Y, Zhang QW, Wu CT, Wang H,Wang LS*. Antitumor effects of oncolytic adenovirus armed with PSA-IZ-CD40L fusion gene against prostate cancer. Gene Ther. 2014;21(8):723-31.
15、Xu FF, Zhu H, Li XM, Yang F, Chen JD, Tang B, Sun HG, Chu YN, Zheng RX, Liu YL,Wang LS*, Zhang Y*. Intercellular adhesion molecule-1 inhibits osteogenic differentiation of mesenchymal stem cells and impairs bio-scaffold-mediated bone regeneration in vivo. Tissue Eng Part A. 2014 Oct;20(19-20):2768-82. IF4.64
16、Wang H, Yang YF, Zhao L, Xiao FJ, Zhang QW, Wen ML, Wu CT, Peng RY,Wang LS*. Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Reduce Radiation-Induced Lung Injury. Hum Gene Ther. 2013:24:343-35. IF3.76
17、Liu Y, Saiyan S, Men TY, Gao HY, Wen C, Liu Y, Zhou X, Wu CT,Wang LS*, Cui CP*. Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. J Pathol. 2013 Aug;230(4):365-76. doi: 10.1002/path.4194. IF7.43
18、Yang Y, Xiao F, Lu Z, Li Z, Zuo H, Zhang Q, Li Q, Wang H,Wang LS*. Development of a novel adenovirus-alphavirus hybrid vector with RNA replicon features for malignant hematopoietic cell transduction. Cancer Gene Ther. 2013;20(8):429-36.
